Title: Clinical Drug Trials in General Practice: a Ten-year Overview of Protocols

I am happy for the article to be accepted after the changes below are made: Minor essential Revisions. Abstract, Conclusions: Please summarise main conclusion here and remove statements to do with methods, such as "We describe a study with several..." Background, Paragraph 1 "in acceptable proportions" can be re-phrased as "proportionate". Methods, Paragraph 1 "Some more details" should be stated as "More detail" Results, Case Study "Some more details" should be stated as "More detail is given" Discussion, Paragraph 4 Amend sentence to "However, a NUMBER of GPs were involved in quite a FEW trials..." Conclusions Suggest rephrasing sentence 6 as follows: "It raises the important ethical considerations with regard to exposing patients to unnecessary risks in either, an inordinately large or a small, under-powered trial."